Reducing Outbreaks

Daily therapy with VALTREX reduces recurrences of genital herpes.1,2

  • VALTREX offers simple once-daily dosing because it has 3 to 5 times greater bioavailability than acyclovir3,4
  • 1 g QD - recommended dosage of VALTREX for patients with recurrent genital herpes
  • 500 mg QD - alternative dosage of VALTREX in patients with <9 recurrences/year
  • Favorable safety profile with daily therapy* - safety and tolerability information on suppression with VALTREX

Patients on VALTREX 1 g QD suppression can be outbreak-free for almost a year*1,2

  • At 1 year, 34% of patients taking VALTREX 1 g once daily stayed outbreak-free vs 4% of patients taking placebo1,2
  • At 1 year, 31% of patients taking VALTREX 500 mg once daily stayed outbreak-free vs 3% of patients taking placebo1,2

Results from a 52-week randomized, prospective, multicenter, double-blind trial of 1479 immunocompetent patients with genital herpes who received daily VALTREX, acyclovir, or placebo. All patients enrolled had a history of 6 or more recurrences/year.

No data are available on the efficacy of treatment of more than 1 year's duration for suppression.

*In immunocompetent adults.

Recommended dosage for suppression is 1 g QD. In patients with ≤9 recurrences/year, an alternative dosage is   500 mg QD.

500-mg data are from a post-hoc subset analysis focused on patients with a history of 6 to 9 recurrences per   year.

  1. Data on file, GlaxoSmithKline.
  2. Reitano M, Tyring S, Lang W, et al. Valaciclovir for the suppression of recurrent genital herpes simplex virus infection: a large-scale dose
    range-finding study. J Infect Dis. 1998;178:603-610.
  3. Weller S, Blum MR, Doucette M, et al. Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single- and multiple-dose administration
    to normal volunteers. Clin Pharmacol Ther. 1993;54:595-605.
  4. Beutner KR, Friedman DJ, Forszpaniak C, Andersen PL, Wood MJ. Valaciclovir compared with acyclovir for improved therapy for herpes zoster in
    immunocompetent adults. Antimicrob Agents Chemother. 1995;39:1546-1553.