Safety Profile

VALTREX offers a favorable safety profile.*

In a 1-year study of daily therapy, the safety profile of VALTREX in adults was comparable to placebo for all dosages, with reported adverse events being generally mild.

Incidence of adverse events with daily suppression
Adverse event (%) VALTREX 1 g QD (n=269) VALTREX 500 mg QD (n=266) Placebo
(n=134)
Nausea 11 11 8
Headache 35 38 34
Vomiting 3 3 2
Dizziness 4 2 1
Abdominal pain 11 9 6
Dysmenorrhea 8 5 4
Arthralgia 6 5 4
Depression 7 5 5

Results from a 52-week randomized, prospective, multicenter, double-blind trial of 1479 immunocompetent patients with genital herpes who received daily VALTREX, acyclovir, or placebo. All patients enrolled had a history of 6 or more recurrences/year.

  • Dosage adjustments should be made in patients with varying degrees of renal dysfunction
  • Pregnancy category B
    - VALTREX should be used during pregnancy only if the potential benefit justifies the potential    risk to the fetus
*In immunocompetent adults.